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<model id="apoptosismodel" >
<listOfCompartments>
<compartment id="default" spatialDimensions="3" />
</listOfCompartments>
<listOfSpecies>
<species id="bax_bcl_2" compartment="default" initialConcentration="0.0" name="bax:bcl-2" />
<species id="daxx" compartment="default" initialConcentration="0.0" name="daxx" />
<species id="ras_gdp" compartment="default" initialConcentration="0.0" name="ras-gdp" />
<species id="srf__a_" compartment="default" initialConcentration="0.0" name="srf (a)" />
<species id="caspase9_iap" compartment="default" initialConcentration="0.0" name="caspase9:iap" />
<species id="c_myc" compartment="default" initialConcentration="0.0" name="c-myc" />
<species id="gsk" compartment="default" initialConcentration="0.0" name="gsk" />
<species id="seb_seb_r" compartment="default" initialConcentration="0.0" name="seb:seb-r" />
<species id="mekk1" compartment="default" initialConcentration="0.0" name="mekk1" />
<species id="mek__a_" compartment="default" initialConcentration="0.0" name="mek (a)" />
<species id="procaspase_3" compartment="default" initialConcentration="0.0" name="procaspase 3" />
<species id="seb" compartment="default" initialConcentration="0.0" name="seb" />
<species id="c_jun" compartment="default" initialConcentration="0.0" name="c-jun" />
<species id="frkh_p14_4_4" compartment="default" initialConcentration="0.0" name="frkh:p14-4-4" />
<species id="nf_kb" compartment="default" initialConcentration="0.0" name="nf-kb" />
<species id="gsk__a_" compartment="default" initialConcentration="0.0" name="gsk (a)" />
<species id="mkk4" compartment="default" initialConcentration="0.0" name="mkk4" />
<species id="bh3__a_" compartment="default" initialConcentration="0.0" name="bh3 (a)" />
<species id="sos" compartment="default" initialConcentration="0.0" name="sos" />
<species id="rac" compartment="default" initialConcentration="0.0" name="rac" />
<species id="pip2" compartment="default" initialConcentration="0.0" name="pip2" />
<species id="cdc25a" compartment="default" initialConcentration="0.0" name="cdc25a" />
<species id="smac" compartment="default" initialConcentration="0.0" name="smac" />
<species id="fas_active" compartment="default" initialConcentration="0.0" name="fas/active" />
<species id="mkk4__a_" compartment="default" initialConcentration="0.0" name="mkk4 (a)" />
<species id="akt" compartment="default" initialConcentration="0.0" name="akt" />
<species id="ras_gtp" compartment="default" initialConcentration="0.0" name="ras-gtp" />
<species id="bax__a_" compartment="default" initialConcentration="0.0" name="bax (a)" />
<species id="mekk1__a_" compartment="default" initialConcentration="0.0" name="mekk1 (a)" />
<species id="c_jun__a_" compartment="default" initialConcentration="0.0" name="c-jun (a)" />
<species id="bcl_2" compartment="default" initialConcentration="0.0" name="bcl-2" />
<species id="p14_3_4" compartment="default" initialConcentration="0.0" name="p14-3-4" />
<species id="egr_1" compartment="default" initialConcentration="0.0" name="egr-1" />
<species id="pak" compartment="default" initialConcentration="0.0" name="pak" />
<species id="nik__a_" compartment="default" initialConcentration="0.0" name="nik (a)" />
<species id="ikb" compartment="default" initialConcentration="0.0" name="ikb" />
<species id="iap" compartment="default" initialConcentration="0.0" name="iap" />
<species id="ras__membrane_" compartment="default" initialConcentration="0.0" name="ras (membrane)" />
<species id="caspase_8__a_" compartment="default" initialConcentration="0.0" name="caspase 8 (a)" />
<species id="ap_1" compartment="default" initialConcentration="0.0" name="ap-1" />
<species id="creb" compartment="default" initialConcentration="0.0" name="creb" />
<species id="creb__a_" compartment="default" initialConcentration="0.0" name="creb (a)" />
<species id="pten" compartment="default" initialConcentration="0.0" name="pten" />
<species id="cdk4" compartment="default" initialConcentration="0.0" name="cdk4" />
<species id="mek" compartment="default" initialConcentration="0.0" name="mek" />
<species id="dp1" compartment="default" initialConcentration="0.0" name="dp1" />
<species id="sos_seb_r" compartment="default" initialConcentration="0.0" name="sos:seb-r" />
<species id="franesyl_tranferase" compartment="default" initialConcentration="0.0" name="franesyl-tranferase" />
<species id="ikb_nf_kb" compartment="default" initialConcentration="0.0" name="ikb:nf-kb" />
<species id="pi3k__a_" compartment="default" initialConcentration="0.0" name="pi3k (a)" />
<species id="bax" compartment="default" initialConcentration="0.0" name="bax" />
<species id="mkp__a_" compartment="default" initialConcentration="0.0" name="mkp (a)" />
<species id="c_fos" compartment="default" initialConcentration="0.0" name="c-fos" />
<species id="pak__a_" compartment="default" initialConcentration="0.0" name="pak (a)" />
<species id="mkp" compartment="default" initialConcentration="0.0" name="mkp" />
<species id="caspase_9" compartment="default" initialConcentration="0.0" name="caspase 9" />
<species id="pi3k" compartment="default" initialConcentration="0.0" name="pi3k" />
<species id="ikb__p_" compartment="default" initialConcentration="0.0" name="ikb (p)" />
<species id="c_myc__a_" compartment="default" initialConcentration="0.0" name="c-myc (a)" />
<species id="caspase3_iap" compartment="default" initialConcentration="0.0" name="caspase3:iap" />
<species id="caspase8" compartment="default" initialConcentration="0.0" name="caspase8" />
<species id="iap_smac" compartment="default" initialConcentration="0.0" name="iap:smac" />
<species id="jnk" compartment="default" initialConcentration="0.0" name="jnk" />
<species id="ikk__a_" compartment="default" initialConcentration="0.0" name="ikk (a)" />
<species id="tnf_a" compartment="default" initialConcentration="0.0" name="tnf-a" />
<species id="fkhr__p_" compartment="default" initialConcentration="0.0" name="fkhr (p)" />
<species id="rac__a_" compartment="default" initialConcentration="0.0" name="rac (a)" />
<species id="ikk" compartment="default" initialConcentration="0.0" name="ikk" />
<species id="ets" compartment="default" initialConcentration="0.0" name="ets" />
<species id="apoptosiscell" compartment="default" initialConcentration="0.0" name="apoptosiscell" />
<species id="bh3" compartment="default" initialConcentration="0.0" name="bh3" />
<species id="jnk__a_" compartment="default" initialConcentration="0.0" name="jnk (a)" />
<species id="cytochrome_c" compartment="default" initialConcentration="0.0" name="cytochrome c" />
<species id="caspase_3" compartment="default" initialConcentration="0.0" name="caspase 3" />
<species id="erk__a_" compartment="default" initialConcentration="0.0" name="erk (a)" />
<species id="nik" compartment="default" initialConcentration="0.0" name="nik" />
<species id="akt__a_" compartment="default" initialConcentration="0.0" name="akt (a)" />
<species id="srf" compartment="default" initialConcentration="0.0" name="srf" />
<species id="erk" compartment="default" initialConcentration="0.0" name="erk" />
<species id="trail" compartment="default" initialConcentration="0.0" name="trail" />
<species id="tnfrsf6" compartment="default" initialConcentration="0.0" name="tnfrsf6" />
<species id="fkhr" compartment="default" initialConcentration="0.0" name="fkhr" />
<species id="pro_caspase_9" compartment="default" initialConcentration="0.0" name="pro-caspase 9" />
<species id="raf__a_" compartment="default" initialConcentration="0.0" name="raf (a)" />
<species id="seb_r" compartment="default" initialConcentration="0.0" name="seb-r" />
<species id="bh3_bcl_2" compartment="default" initialConcentration="0.0" name="bh3:bcl-2" />
<species id="raf" compartment="default" initialConcentration="0.0" name="raf" />
<species id="ets__a_" compartment="default" initialConcentration="0.0" name="ets (a)" />
<species id="fasl__tnfsf6_" compartment="default" initialConcentration="0.0" name="fasl (tnfsf6)" />
<species id="pip3" compartment="default" initialConcentration="0.0" name="pip3" />
</listOfSpecies>
<listOfReactions>
<reaction id="Regulated_production" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="c_myc" stoichiometry="10" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_0" reversible="false" >
<listOfReactants>
<speciesReference species="trail" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase_8__a_" stoichiometry="3" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_0</ci>
<ci >
trail</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_0" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_1" reversible="false" >
<listOfReactants>
<speciesReference species="bax__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="cytochrome_c" stoichiometry="4" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_1</ci>
<ci >
bax__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_1" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_2" reversible="false" >
<listOfReactants>
<speciesReference species="nf_kb" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="iap" stoichiometry="6" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_2</ci>
<ci >
nf_kb</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_2" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation" reversible="false" >
<listOfReactants>
<speciesReference species="akt" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation</ci>
<ci >
akt</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_3" reversible="false" >
<listOfReactants>
<speciesReference species="egr_1" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="fasl__tnfsf6_" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_3</ci>
<ci >
egr_1</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_3" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_4" reversible="false" >
<listOfReactants>
<speciesReference species="tnf_a" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase_8__a_" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_4</ci>
<ci >
tnf_a</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_4" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_0" reversible="false" >
<listOfReactants>
<speciesReference species="iap_smac" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_0</ci>
<ci >
iap_smac</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_0" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Production" reversible="false" >
<listOfProducts>
<speciesReference species="akt" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<ci >
k_Production</ci>
</math:math>
<listOfParameters>
<parameter id="k_Production" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction" reversible="false" >
<listOfReactants>
<speciesReference species="jnk" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="jnk__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mkk4__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction</ci>
<ci >
mkk4__a_</ci>
<ci >
jnk</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction</ci>
<ci >
jnk</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction" reversible="false" >
<listOfReactants>
<speciesReference species="ikk__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ikk" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction</ci>
<ci >
ikk__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_0" reversible="false" >
<listOfReactants>
<speciesReference species="mkk4" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="mkk4__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mekk1__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_0</ci>
<ci >
mekk1__a_</ci>
<ci >
mkk4</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_0</ci>
<ci >
mkk4</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_0" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_0" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_0" reversible="false" >
<listOfReactants>
<speciesReference species="smac" >
</speciesReference>
<speciesReference species="iap" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="iap_smac" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_0</ci>
<ci >
smac</ci>
<ci >
iap</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_0" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_1" reversible="false" >
<listOfReactants>
<speciesReference species="creb" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="creb__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="gsk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_1</ci>
<ci >
gsk__a_</ci>
<ci >
creb</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_1</ci>
<ci >
creb</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_1" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_1" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_1" reversible="false" >
<listOfReactants>
<speciesReference species="gsk__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="gsk" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_1</ci>
<ci >
gsk__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_1" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_2" reversible="false" >
<listOfReactants>
<speciesReference species="sos_seb_r" >
</speciesReference>
<speciesReference species="ras_gdp" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="seb_r" >
</speciesReference>
<speciesReference species="sos" >
</speciesReference>
<speciesReference species="ras_gtp" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_2</ci>
<ci >
sos_seb_r</ci>
<ci >
ras_gdp</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_2" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_5" reversible="false" >
<listOfReactants>
<speciesReference species="nf_kb" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="tnf_a" stoichiometry="4" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_5</ci>
<ci >
nf_kb</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_5" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_6" reversible="false" >
<listOfReactants>
<speciesReference species="caspase_8__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bh3__a_" stoichiometry="3" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_6</ci>
<ci >
caspase_8__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_6" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_3" >
<listOfReactants>
<speciesReference species="seb" >
</speciesReference>
<speciesReference species="seb_r" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="seb_seb_r" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_3</ci>
<ci >
seb_r</ci>
<ci >
seb</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_3</ci>
<ci >
seb_seb_r</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_3" value="1.0" name="kf" />
<parameter id="kr_Reaction_3" value="0.1" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_1" reversible="false" >
<listOfReactants>
<speciesReference species="sos" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_1</ci>
<ci >
sos</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_1" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_7" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="cdk4" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_7</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_7" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_4" reversible="false" >
<listOfReactants>
<speciesReference species="fkhr__p_" >
</speciesReference>
<speciesReference species="p14_3_4" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="frkh_p14_4_4" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_4</ci>
<ci >
fkhr__p_</ci>
<ci >
p14_3_4</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_4" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_8" reversible="false" >
<listOfReactants>
<speciesReference species="ap_1" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="c_myc" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_8</ci>
<ci >
ap_1</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_8" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_5" reversible="false" >
<listOfReactants>
<speciesReference species="nik__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="nik" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_5</ci>
<ci >
nik__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_5" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_2" reversible="false" >
<listOfReactants>
<speciesReference species="fkhr" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="fkhr__p_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="akt__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_2</ci>
<ci >
akt__a_</ci>
<ci >
fkhr</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_2</ci>
<ci >
fkhr</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_2" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_2" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_9" reversible="false" >
<listOfReactants>
<speciesReference species="srf__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="c_fos" stoichiometry="5" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_9</ci>
<ci >
srf__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_9" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Production_0" reversible="false" >
<listOfProducts>
<speciesReference species="pro_caspase_9" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<ci >
k_Production_0</ci>
</math:math>
<listOfParameters>
<parameter id="k_Production_0" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_6" >
<listOfReactants>
<speciesReference species="ikb" >
</speciesReference>
<speciesReference species="nf_kb" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ikb_nf_kb" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_6</ci>
<ci >
ikb</ci>
<ci >
nf_kb</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_6</ci>
<ci >
ikb_nf_kb</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_6" value="1.0" name="kf" />
<parameter id="kr_Reaction_6" value="0.2" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_7" >
<listOfReactants>
<speciesReference species="c_fos" >
</speciesReference>
<speciesReference species="c_jun__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ap_1" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_7</ci>
<ci >
c_jun__a_</ci>
<ci >
c_fos</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_7</ci>
<ci >
ap_1</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_7" value="1.0" name="kf" />
<parameter id="kr_Reaction_7" value="0.2" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_10" reversible="false" >
<listOfReactants>
<speciesReference species="bax__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="smac" stoichiometry="4" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_10</ci>
<ci >
bax__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_10" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_8" reversible="false" >
<listOfReactants>
<speciesReference species="akt__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="akt" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_8</ci>
<ci >
akt__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_8" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_3" reversible="false" >
<listOfReactants>
<speciesReference species="gsk" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="gsk__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="erk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_3</ci>
<ci >
erk__a_</ci>
<ci >
gsk</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_3</ci>
<ci >
gsk</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_3" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_3" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_11" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="cdc25a" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_11</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_11" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_12" reversible="false" >
<listOfReactants>
<speciesReference species="caspase_3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="apoptosiscell" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_12</ci>
<ci >
caspase_3</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_12" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_2" reversible="false" >
<listOfReactants>
<speciesReference species="caspase9_iap" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_2</ci>
<ci >
caspase9_iap</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_2" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_4" reversible="false" >
<listOfReactants>
<speciesReference species="pro_caspase_9" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase_9" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="cytochrome_c" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_4</ci>
<ci >
cytochrome_c</ci>
<ci >
pro_caspase_9</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_4</ci>
<ci >
pro_caspase_9</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_4" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_4" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_5" reversible="false" >
<listOfReactants>
<speciesReference species="mkp" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="mkp__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="erk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_5</ci>
<ci >
erk__a_</ci>
<ci >
mkp</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_5</ci>
<ci >
mkp</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_5" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_5" value="1.0" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_9" reversible="false" >
<listOfReactants>
<speciesReference species="akt" >
</speciesReference>
<speciesReference species="pip3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="akt__a_" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_9</ci>
<ci >
akt</ci>
<ci >
pip3</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_9" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_3" reversible="false" >
<listOfReactants>
<speciesReference species="caspase3_iap" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_3</ci>
<ci >
caspase3_iap</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_3" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_10" >
<listOfReactants>
<speciesReference species="daxx" >
</speciesReference>
<speciesReference species="tnfrsf6" >
</speciesReference>
<speciesReference species="fasl__tnfsf6_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="fas_active" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_10</ci>
<ci >
tnfrsf6</ci>
<ci >
fasl__tnfsf6_</ci>
<ci >
daxx</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_10</ci>
<ci >
fas_active</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_10" value="1.0" name="kf" />
<parameter id="kr_Reaction_10" value="0.2" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_13" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="tnfrsf6" stoichiometry="6" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_13</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_13" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_6" reversible="false" >
<listOfReactants>
<speciesReference species="erk" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="erk__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mek__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_6</ci>
<ci >
mek__a_</ci>
<ci >
erk</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_6</ci>
<ci >
erk</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_6" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_6" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_7" reversible="false" >
<listOfReactants>
<speciesReference species="srf" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="srf__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="erk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_7</ci>
<ci >
erk__a_</ci>
<ci >
srf</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_7</ci>
<ci >
srf</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_7" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_7" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_11" reversible="false" >
<listOfReactants>
<speciesReference species="srf__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="srf" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_11</ci>
<ci >
srf__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_11" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Production_1" reversible="false" >
<listOfProducts>
<speciesReference species="procaspase_3" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<ci >
k_Production_1</ci>
</math:math>
<listOfParameters>
<parameter id="k_Production_1" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_8" reversible="false" >
<listOfReactants>
<speciesReference species="pip3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="pip2" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="pten" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_8</ci>
<ci >
pten</ci>
<ci >
pip3</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_8</ci>
<ci >
pip3</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_8" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_8" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_14" reversible="false" >
<listOfReactants>
<speciesReference species="nf_kb" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bcl_2" stoichiometry="5" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_14</ci>
<ci >
nf_kb</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_14" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_9" reversible="false" >
<listOfReactants>
<speciesReference species="fkhr__p_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="fkhr" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="cdc25a" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_9</ci>
<ci >
cdc25a</ci>
<ci >
fkhr__p_</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_9</ci>
<ci >
fkhr__p_</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_9" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_9" value="1.0" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_12" reversible="false" >
<listOfReactants>
<speciesReference species="mekk1__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="mekk1" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_12</ci>
<ci >
mekk1__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_12" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_13" >
<listOfReactants>
<speciesReference species="bh3__a_" >
</speciesReference>
<speciesReference species="bcl_2" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bh3_bcl_2" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_13</ci>
<ci >
bcl_2</ci>
<ci >
bh3__a_</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_13</ci>
<ci >
bh3_bcl_2</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_13" value="1.0" name="kf" />
<parameter id="kr_Reaction_13" value="0.5" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_14" reversible="false" >
<listOfReactants>
<speciesReference species="pak__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="pak" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_14</ci>
<ci >
pak__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_14" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_10" reversible="false" >
<listOfReactants>
<speciesReference species="ras_gtp" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ras__membrane_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="franesyl_tranferase" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_10</ci>
<ci >
franesyl_tranferase</ci>
<ci >
ras_gtp</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_10</ci>
<ci >
ras_gtp</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_10" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_10" value="1.0" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_15" reversible="false" >
<listOfReactants>
<speciesReference species="egr_1" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="egr_1" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_15</ci>
<ci >
egr_1</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_15" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_4" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_4</ci>
<ci >
c_myc</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_4" value="3.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_11" reversible="false" >
<listOfReactants>
<speciesReference species="bax" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bax__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="bh3__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_11</ci>
<ci >
bh3__a_</ci>
<ci >
bax</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_11</ci>
<ci >
bax</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_11" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_11" value="1.0" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_5" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_5</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_5" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_12" reversible="false" >
<listOfReactants>
<speciesReference species="c_jun" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="c_jun__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="jnk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_12</ci>
<ci >
jnk__a_</ci>
<ci >
c_jun</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_12</ci>
<ci >
c_jun</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_12" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_12" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_15" reversible="false" >
<listOfReactants>
<speciesReference species="jnk__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="jnk" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_15</ci>
<ci >
jnk__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_15" value="0.2" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_6" reversible="false" >
<listOfReactants>
<speciesReference species="pten" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_6</ci>
<ci >
pten</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_6" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_16" reversible="false" >
<listOfReactants>
<speciesReference species="mek__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="mek" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_16</ci>
<ci >
mek__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_16" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_16" reversible="false" >
<listOfReactants>
<speciesReference species="ap_1" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="c_fos" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_16</ci>
<ci >
ap_1</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_16" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_13" reversible="false" >
<listOfReactants>
<speciesReference species="procaspase_3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase_3" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="caspase_8__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_13</ci>
<ci >
caspase_8__a_</ci>
<ci >
procaspase_3</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_13</ci>
<ci >
procaspase_3</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_13" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_13" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_17" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="trail" stoichiometry="6" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_17</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_17" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Production_2" reversible="false" >
<listOfProducts>
<speciesReference species="mkp" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<ci >
k_Production_2</ci>
</math:math>
<listOfParameters>
<parameter id="k_Production_2" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_14" reversible="false" >
<listOfReactants>
<speciesReference species="ikb" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ikb__p_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="ikk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_14</ci>
<ci >
ikk__a_</ci>
<ci >
ikb</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_14</ci>
<ci >
ikb</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_14" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_14" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_18" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bax" stoichiometry="7" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_18</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_18" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_17" reversible="false" >
<listOfReactants>
<speciesReference species="iap" >
</speciesReference>
<speciesReference species="caspase_3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase3_iap" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_17</ci>
<ci >
iap</ci>
<ci >
caspase_3</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_17" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_7" reversible="false" >
<listOfReactants>
<speciesReference species="mkp__a_" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_7</ci>
<ci >
mkp__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_7" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_19" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="fasl__tnfsf6_" stoichiometry="5" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_19</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_19" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Production_3" reversible="false" >
<listOfProducts>
<speciesReference species="c_jun" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<ci >
k_Production_3</ci>
</math:math>
<listOfParameters>
<parameter id="k_Production_3" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_20" reversible="false" >
<listOfReactants>
<speciesReference species="ets__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="egr_1" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_20</ci>
<ci >
ets__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_20" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_15" reversible="false" >
<listOfReactants>
<speciesReference species="bh3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bh3__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="jnk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_15</ci>
<ci >
jnk__a_</ci>
<ci >
bh3</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_15</ci>
<ci >
bh3</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_15" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_15" value="1.0" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_21" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="pten" stoichiometry="5" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_21</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_21" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_8" reversible="false" >
<listOfReactants>
<speciesReference species="akt__a_" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_8</ci>
<ci >
akt__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_8" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_18" reversible="false" >
<listOfReactants>
<speciesReference species="mkk4__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="mkk4" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_18</ci>
<ci >
mkk4__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_18" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_22" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="daxx" stoichiometry="6" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_22</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_22" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_19" >
<listOfReactants>
<speciesReference species="rac" >
</speciesReference>
<speciesReference species="pip3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="rac__a_" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_19</ci>
<ci >
rac</ci>
<ci >
pip3</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_19</ci>
<ci >
rac__a_</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_19" value="1.0" name="kf" />
<parameter id="kr_Reaction_19" value="0.5" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_16" reversible="false" >
<listOfReactants>
<speciesReference species="procaspase_3" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase_3" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="caspase_9" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_16</ci>
<ci >
caspase_9</ci>
<ci >
procaspase_3</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_16</ci>
<ci >
procaspase_3</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_16" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_16" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_17" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="erk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_17</ci>
<ci >
erk__a_</ci>
<ci >
c_myc</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_17</ci>
<ci >
c_myc</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_17" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_17" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_23" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase8" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_23</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_23" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_24" reversible="false" >
<listOfReactants>
<speciesReference species="fkhr" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bh3" stoichiometry="10" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_24</ci>
<ci >
fkhr</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_24" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_20" reversible="false" >
<listOfReactants>
<speciesReference species="ras__membrane_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ras_gdp" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_20</ci>
<ci >
ras__membrane_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_20" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_9" reversible="false" >
<listOfReactants>
<speciesReference species="c_jun" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_9</ci>
<ci >
c_jun</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_9" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_10" reversible="false" >
<listOfReactants>
<speciesReference species="ikb__p_" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_10</ci>
<ci >
ikb__p_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_10" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_18" reversible="false" >
<listOfReactants>
<speciesReference species="mekk1" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="mekk1__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="rac__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_18</ci>
<ci >
rac__a_</ci>
<ci >
mekk1</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_18</ci>
<ci >
mekk1</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_18" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_18" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_19" reversible="false" >
<listOfReactants>
<speciesReference species="nik" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="nik__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="erk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_19</ci>
<ci >
erk__a_</ci>
<ci >
nik</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_19</ci>
<ci >
nik</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_19" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_19" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_21" >
<listOfReactants>
<speciesReference species="raf" >
</speciesReference>
<speciesReference species="ras__membrane_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="raf__a_" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_21</ci>
<ci >
ras__membrane_</ci>
<ci >
raf</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_21</ci>
<ci >
raf__a_</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_21" value="1.0" name="kf" />
<parameter id="kr_Reaction_21" value="0.5" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Production_4" reversible="false" >
<listOfProducts>
<speciesReference species="sos" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<ci >
k_Production_4</ci>
</math:math>
<listOfParameters>
<parameter id="k_Production_4" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_20" reversible="false" >
<listOfReactants>
<speciesReference species="erk__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="erk" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mkp__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_20</ci>
<ci >
mkp__a_</ci>
<ci >
erk__a_</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_20</ci>
<ci >
erk__a_</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_20" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_20" value="1.0" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_21" reversible="false" >
<listOfReactants>
<speciesReference species="ets" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ets__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="erk__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_21</ci>
<ci >
erk__a_</ci>
<ci >
ets</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_21</ci>
<ci >
ets</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_21" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_21" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_11" reversible="false" >
<listOfReactants>
<speciesReference species="c_jun__a_" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_11</ci>
<ci >
c_jun__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_11" value="0.2" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_22" >
<listOfReactants>
<speciesReference species="bax" >
</speciesReference>
<speciesReference species="bcl_2" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="bax_bcl_2" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_22</ci>
<ci >
bcl_2</ci>
<ci >
bax</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_22</ci>
<ci >
bax_bcl_2</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_22" value="1.0" name="kf" />
<parameter id="kr_Reaction_22" value="0.5" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_22" reversible="false" >
<listOfReactants>
<speciesReference species="pak" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="pak__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="rac__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_22</ci>
<ci >
rac__a_</ci>
<ci >
pak</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_22</ci>
<ci >
pak</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_22" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_22" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_25" reversible="false" >
<listOfReactants>
<speciesReference species="c_myc__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="dp1" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_25</ci>
<ci >
c_myc__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_25" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_23" >
<listOfReactants>
<speciesReference species="seb_seb_r" >
</speciesReference>
<speciesReference species="sos" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="sos_seb_r" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_23</ci>
<ci >
sos</ci>
<ci >
seb_seb_r</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_23</ci>
<ci >
sos_seb_r</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_23" value="1.0" name="kf" />
<parameter id="kr_Reaction_23" value="0.1" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_24" reversible="false" >
<listOfReactants>
<speciesReference species="iap" >
</speciesReference>
<speciesReference species="caspase_9" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase9_iap" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_24</ci>
<ci >
iap</ci>
<ci >
caspase_9</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_24" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_12" reversible="false" >
<listOfReactants>
<speciesReference species="mkp" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_12</ci>
<ci >
mkp</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_12" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_23" reversible="false" >
<listOfReactants>
<speciesReference species="mek" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="mek__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="raf__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_23</ci>
<ci >
raf__a_</ci>
<ci >
mek</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_23</ci>
<ci >
mek</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_23" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_23" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_13" reversible="false" >
<listOfReactants>
<speciesReference species="egr_1" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_13</ci>
<ci >
egr_1</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_13" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Production_5" reversible="false" >
<listOfProducts>
<speciesReference species="ikb" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<ci >
k_Production_5</ci>
</math:math>
<listOfParameters>
<parameter id="k_Production_5" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_24" reversible="false" >
<listOfReactants>
<speciesReference species="pip2" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="pip3" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="pi3k__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_24</ci>
<ci >
pi3k__a_</ci>
<ci >
pip2</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_24</ci>
<ci >
pip2</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_24" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_24" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_25" reversible="false" >
<listOfReactants>
<speciesReference species="caspase8" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="caspase_8__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="fas_active" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_25</ci>
<ci >
fas_active</ci>
<ci >
caspase8</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_25</ci>
<ci >
caspase8</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_25" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_25" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_25" >
<listOfReactants>
<speciesReference species="pi3k" >
</speciesReference>
<speciesReference species="ras__membrane_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="pi3k__a_" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<minus >
</minus>
<apply >
<times >
</times>
<ci >
kf_Reaction_25</ci>
<ci >
pi3k</ci>
<ci >
ras__membrane_</ci>
</apply>
<apply >
<times >
</times>
<ci >
kr_Reaction_25</ci>
<ci >
pi3k__a_</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="kf_Reaction_25" value="1.0" name="kf" />
<parameter id="kr_Reaction_25" value="0.5" name="kr" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Reaction_26" reversible="false" >
<listOfReactants>
<speciesReference species="ets__a_" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ets" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Reaction_26</ci>
<ci >
ets__a_</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Reaction_26" value="0.5" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Degradation_14" reversible="false" >
<listOfReactants>
<speciesReference species="c_fos" >
</speciesReference>
</listOfReactants>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Degradation_14</ci>
<ci >
c_fos</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Degradation_14" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_reaction_26" reversible="false" >
<listOfReactants>
<speciesReference species="ikk" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="ikk__a_" >
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="nik__a_" >
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw >
<math:math>
<apply >
<divide >
</divide>
<apply >
<times >
</times>
<ci >
k_cat_Regulated_reaction_26</ci>
<ci >
nik__a_</ci>
<ci >
ikk</ci>
</apply>
<apply >
<plus/>
<ci >
K_M_Regulated_reaction_26</ci>
<ci >
ikk</ci>
</apply>
</apply>
</math:math>
<listOfParameters>
<parameter id="K_M_Regulated_reaction_26" value="1.0" name="K_M" />
<parameter id="k_cat_Regulated_reaction_26" value="0.5" name="k_cat" />
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Regulated_production_26" reversible="false" >
<listOfReactants>
<speciesReference species="ap_1" >
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="tnf_a" >
</speciesReference>
</listOfProducts>
<kineticLaw >
<math:math>
<apply >
<times >
</times>
<ci >
k_Regulated_production_26</ci>
<ci >
ap_1</ci>
</apply>
</math:math>
<listOfParameters>
<parameter id="k_Regulated_production_26" value="1.0" name="k" />
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>

